Urticaria pigmentosa
Urticaria pigmentosa teri mastositozining eng keng tarqalgan shaklidir. Bu teridagi mast hujayralarining haddan tashqari ko'pligi tufayli yuzaga keladigan kam uchraydigan kasallik bo'lib, tirnash xususiyati bilan terida ürtiker yoki yaralar paydo bo'ladi. Qizil yoki jigarrang dog'lar ko'pincha terida, odatda ko'krak, peshona va orqada ko'rinadi. Bu mast hujayralari tirnash xususiyati bilan (masalan, terini ishqalash, issiqlik ta'sirida) haddan tashqari ko'p gistamin ishlab chiqaradi, bu esa tirnash xususiyati beruvchi hududda lokalizatsiya qilingan, ba'zan "Darier belgisi" deb ataladigan uyalar paydo bo'lishiga olib keladigan allergik reaktsiyani keltirib chiqaradi.
☆ Germaniyaning 2022 yilgi Stiftung Warentest natijalariga ko'ra, iste'molchilarning ModelDermdan qoniqish darajasi pullik teletibbiyot maslahatlariga qaraganda bir oz pastroq bo'lgan.
Odatda yosh bolalarning tanasida paydo bo'ladi.
References
Mastocytosis - teri, suyak iligi va ovqat hazm qilish tizimi kabi tananing turli qismlarida ko'p miqdorda mast hujayralari mavjud bo'lgan holat. Jahon sog'liqni saqlash tashkiloti (JSST) ma'lumotlariga ko'ra, cutaneous mastocytosis ni uchta asosiy turga bo'lish mumkin. Birinchi turdagi (mastocytomas) soliter yoki bir nechta (≤3) jarohatlardan iborat. Ikkinchi tur (urticaria pigmentosa) ko'p jarohatlarni o'z ichiga oladi, odatda 10 dan ortiq 100 dan kamroq. Oxirgi turi teri bo'ylab keng tarqalgan ishtirokini ko'rsatadi. Urticaria pigmentosa - bolalarda teri mastositozining eng keng tarqalgan shakli, ammo u kattalarda ham paydo bo'lishi mumkin. Bu odatda o'smirlik davrida yaxshilanadigan zararsiz holat. Katta yoshdagi mastositozdan farqli o'laroq, urticaria pigmentosa kamdan-kam hollarda ichki organlarga ta'sir qiladi. Urticaria pigmentosa ning o'ziga xos xususiyatlaridan biri bu terida mayda, qichima, qizil-jigarrang yoki sarg'ish-jigarrang dog'lar yoki jarohatlar paydo bo'lishiga moyillikdir, odatda ürtiker deb ataladi. Bu dog'lar odatda bolalikda paydo bo'ladi va hayot davomida davom etishi mumkin.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
6 yoshli qizaloq birinchi marta bosh terisida paydo bo'lgan, so'ngra oxirgi olti oy ichida yuzi va tanasiga tarqalgan bir nechta quyuq rangli dog'lar bilan keldi. U bosim o'tkazilganda ularning ko'tarilishi, qizarishi va qichishishini his qildi. U qizarish, qusish, diareya yoki xirillashni boshdan kechirmagan, shaxsiy va oilaviy tibbiy tarixi tegishli maslahatlar bermagan. Tekshiruv chog'ida biz uning bosh terisi, peshonasi, yuzi va bo'ynida bir nechta qora dog'lar, ko'kragi va orqa tomonida biroz ko'tarilgan qora dog'lar topdik. Dog'larni engil ishqalash 2 daqiqada shishib va qichishishiga olib keldi, ammo alomatlar 15-20 daqiqada yo'qoldi (Darier's sign) .
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
